Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. Pommier P, Gomez F, Sunyach MP, D’Hombres A, Carrie C, Montbarbon X. Lotion Soft Skin Conditioner Skin Cream Safety Data Sheet. Moisturizers: what they are and a practical approach to product selection. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Randomized, paired comparison of no-sting barrier film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation. Graham P, Browne L, Capp A, Fox C, Graham J, Hollis J, et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Heggie S, Bryant GP, Tripcony L, Keller J, Rose P, Glendenning M, et al. Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial. Hindley A, Zain Z, Wood L, Whitehead A, Sanneh A, Barber D, et al. Topical corticosteroid therapy for the prevention of acute radiation dermatitis: a systematic review of randomized controlled trials. Meghrajani CF, Co HC, Ang-Tiu CM, Roa FC. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Wells M, Macmillan M, Raab G, MacBride S, Bell N, MacKinnon K, et al. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams. doi: 10.1007/s0052-6.ĭi Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, et al. Acute skin toxicity-related, out-of-pocket expenses in patients with breast cancer treated with external beam radiotherapy: a descriptive, exploratory study. Schnur JB, Graff Zivin J, Mattson Jr DM, Green S, Jandorf LH, Wernicke AG, et al. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. Evidence-based skin care management in radiation therapy: clinical update. Evidence-based skin care management in radiation therapy. Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Wong RK, Bensadoun RJ, Boers-Doets CB, Bryce J, Chan A, Epstein JB, et al. Skin care products used during radiation therapy.Products covered in this chapter include moisturizers and emollients such as Lotion Soft, Remedy Lotion, calendula, petroleum-based bland emollients, trolamine, EpiCeram, hyaluronic acid, sucralfate, and emu oil topical steroids miscellaneous products such as RadiaGel and wound cleansers/antiseptics drying agents topical anti-infective agents Mānuka honey skin barriers and dressings including hydrophilic/hydrogels, Mepilex Lite, and silver ion. However, some products have not been evaluated in a controlled setting but have demonstrated utility and are commonly used by consensus opinion. Some of these products have been investigated and have or have not been shown to significantly benefit patients by decreasing radiation reactions. In this chapter we explore some of the more commonly used skin care products available for patients undergoing radiation therapy. Trials focused on the effectiveness of products are beginning to address the need and desire for more evidence-based practice in this population. At present, there is limited and insufficient evidence, with the exception of prophylactic topical steroid creams, to support the use of any specific topical agent over another for the prevention of radiation dermatitis. A multitude of prescription and nonprescription skin care products are currently available for patients undergoing radiation therapy. At this time there is no standard of care for the prevention and management of skin reactions in the radiation oncology patient population.
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